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M94A3089.TXT
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1994-10-25
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Document 3089
DOCN M94A3089
TI Predictive value of symptomatic primary acute HIV-1 infection: a two
years evaluation following contamination.
DT 9412
AU Derancourt C; el M'Rini T; Borne MC; Drobacheff C; Vuitton D; Leroy J;
Portier H; Laurent R; Department of Dermatology and Cellule Sida,
University Hospital,; Besancon, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):156 (abstract no. PB0051). Unique
Identifier : AIDSLINE ICA10/94369486
AB OBJECTIVE: To determine, two years following contamination, the
predictive value of symptomatic primary HIV 1 infection (CDC
classification, CD4 cells count) compared to asymptomatic
seroconversion, in a retrospective study. METHODS: Two cohorts including
993 HIV 1 infected patients (1985-1994) were studied: Eleven patients
with a primary symptomatic HIV 1 infection were observed; Seventeen
patients seroconverted for HIV 1 within one year without any symptom.
These two groups were compared two years following contamination in
terms of CDC classification and CD4 cells count. RESULTS: No difference
in CDC classification was found between the two groups. Symptomatic
seroconverters: II: 4; III: 4; IVC2: 2; IVC1: 1; dead: 1 (two patients
with one month duration fever had a rapid progression of the disease);
Asymptomatic seroconverters: II: 6; III: 7; IVC2: 2; IVC1: 2. No
difference in CD4 cells count was found between symptomatics
(481/microliter; +/- SD = 279) and asymptomatics (441/microliter; +/- SD
= 258). CONCLUSION: Previous long term studies disclosed a predictive
value of symptomatic seroconversion in rapid progression of the disease.
Our study doesn't reveal any difference (CDC classification, CD4 cells
count) between symptomatic and asymptomatic patients, two years after
contamination.
DE Acquired Immunodeficiency Syndrome/*CLASSIFICATION/IMMUNOLOGY/
PHYSIOPATHOLOGY Centers for Disease Control and Prevention (U.S.)
Cohort Studies Comparative Study Human HIV
Seropositivity/*CLASSIFICATION/IMMUNOLOGY/PHYSIOPATHOLOGY *HIV-1
Leukocyte Count Predictive Value of Tests Retrospective Studies Time
Factors T4 Lymphocytes United States MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).